Does amoxicillin interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker. Amoxicillin is a modified version of the antibiotic penicillin, designed to have a broader range of effectiveness against bacterial infections. While it is commonly prescribed, potential drug interactions should be considered to ensure safe and effective treatment. Amoxicillin interactions can affect how well the antibiotic works and raise your risk of side effects. Common concerns include combining amoxicillin with warfarin, methotrexate, ibuprofen, or certain supplements. Find out about possible Amoxicillin interactions with alcohol, other drugs, supplements, foods, and more. Unlike some other antibiotics, amoxicillin has few clinically significant food interactions. That said, certain dietary habits may affect how you feel while taking it, particularly if you experience stomach upset. Amoxicillin can interact with medications such as warfarin (Jantoven), allopurinol (Zyloprim), and probenecid (Probalan). It may also interact with alcohol and some live vaccines. Does Amoxil interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker. Use WebMD’s Drug Interaction Checker to identify potential interactions between medications, supplements, and foods. Reduce side effects and support safer treatment decisions. Learn about interactions between Amoxicillin and other medications, supplements, foods, alcohol, and more. You can also find out when to avoid Amoxicillin. See the list of drugs that interact with Amoxicillin. Includes information on severity of interaction and the level of evidence for it.